Klopp rung the changes ahead of the 234th Merseyside derby but the changes did little to affect Liverpool’s incredible momentum.
Divock Origi led the time in place of the rested Roberto Firmino and opened the scoring in the sixth minute after a world-class assist from Mane.
Swiss winger Shaqiri afforded a rare start in place of Mohammed Salah extended the lead in the 17th minute after more superb build-up play from Trent Alexander-Arnold and Mane.
Everton hit back four minutes later when Michael Keane finished an Alex Iwobi cross, but the Reds restored their two goal cushion after his remarkable first touch from a Lovren 50-yard ball set up his lobbed finish over Jordan Pickford.
Mane made if 4-1 on the stroke of half time after a fast-break involving Alexander-Arnold, but Richarlison swiftly equalised from the restart to send the teams in 4-2 at half time.
The second half was a rather more sedate affair, with just one further goal coming late in the piece from the boot of Giorginio Wijnaldum.
The win restored the Reds’ 8 point lead atop the table after closest challengers Leicester won for the seventh successive league match less than an hour before.
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